Most Extensive Face Transplant Ever Undertaken on Burn Victim

Jacob Newberger is a Pennsylvania professional with past experience designing automated systems at Panacea Technologies. With a longstanding interest in medicine, Jacob Newberger is particularly focused on developments in the orthopedics and transplant surgery spheres.

In many ways 2015 was a breakthrough year in medicine, with milestones including the most extensive face transplant ever undertaken. The pioneering treatment involved a volunteer firefighter who suffered severe burns when attempting to rescue a person he believed to be trapped in a burning home. The third-degree burns took all of his head and eyebrow hair, as well as his ears, and made him virtually unrecognizable to friends and family.

An innovative U.S. surgeon undertook a transplant that used donated tissue encompassing the forehead, face, scalp, ears, and eyelids. The surgeon also replaced a certain number of the nerves, blood vessels, and muscles under the skin. The result was a “hybrid” face that combined some of the patients’ facial features with those of his donor, who had been killed in a cycling incident.

Three months after the surgery, the patient was described as being in excellent condition and leading an independent life. In particular, transplant areas such as the ears and lips exhibited good color, a sign that blood circulation has been repaired.

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Panacea – Innovative Technologies to Improve Automation

Panacea Technologies, Inc pic
Panacea Technologies, Inc
Image: panaceatech.com

Jacob Newberger has spent the past five years of his professional life establishing experience in the automation field and currently works as an automation validation engineer. Panacea Technologies, Inc., the company that employes Jacob Newberger, has been instrumental in establishing automated processes for vaccine manufacturers.

According to the company’s web site, panaceatech.com, Panacea assisted a vaccine company by overseeing the process of establishing standards for automating the company’s systems interactions. One of the tools used in this project was the Control Logix/Archestra framework designed by Panacea. This framework makes the system configuration process easier with a distributed control system, which allows for the dissemination of control elements across the system, rather than having one element in a central location.

The Control Logix/Archestra framework also utilizes PLC/SCADA architecture, which reduces cost. A PLC (programmable logic controller) allows for automation through a digital computer; a SCADA (supervisory control and data acquisition) system enables remote equipment control by sending coded signals.

Professional Athletes Benefit from Improvements in ACL Repair

An automation validation engineer with Panacea Technologies, Inc., in Montgomeryville, Pennsylvania, Jacob Newberger maintains a number of interests outside of his profession. Among other things, Jacob Newberger follows the latest advances in orthopedic surgery.

Orthopedic injuries come in all shapes and sizes, ranging from carpal tunnel syndrome to more serious conditions such as a tear in the anterior cruciate ligament (ACL) in the knee. Professional athletes are particularly susceptible to ACL tears, especially basketball and football players, such as Chicago Bulls guard Derrick Rose and Adrian Peterson of the Minnesota Vikings. In the past, these kinds of injuries could spell the end of a player’s career or, at the very least, prevent players from ever regaining their previous form.

However, advances in modern medicine have allowed several players to successfully rebound from an ACL tear. Peterson’s story is most often cited as an example of how far sports and orthopedic medicine have come. In 2012, Peterson returned to the National Football League (NFL) only six months after tearing his ACL. The short recovery period was itself an impressive feat. However, Peterson did more than just rebound from his ACL tear. The season following his surgery, the running back averaged 19 yards per carry, a career best, and came within one carry of breaking the league’s single-season rushing record. While an ACL tear is still a very serious injury for pro athletes, such recovery stories provide hope for them as well as average people who simply wish to regain full range of motion in their knee.

An Overview of Stem Cell Therapy for Orthopaedics

Jacob Newberger currently works at Panacea Technologies, Inc., as an automation validation engineer. Outside of work Jacob Newberger enjoys learning about medicine, particularly transplant surgeries and orthopaedic procedures.

In recent years stem cell therapy has been used to treat a number of conditions throughout the human body, including several musculoskeletal disorders. Bone grafts and surgical implants represented the primary medical response to orthopaedic disorders for many years, though more recently stem cell tissue engineering has attracted considerable interest among the orthopaedic community.

Medical professionals have long been aware of bone morphogenetic proteins thanks to the discovery of Marshall Urist, MD. While a number of proteins have been identified as osteoinductive and osteoconductive throughout the process of osteogenesis, the smallest variables in the body’s microenvironment can dictate the success of a protein implant procedure. Stem cells, on the other hand, can be viewed as blank pages. Unlike proteins, each stem cell is capable of producing a variety of paracrine modulators. A stem cell’s capacity for renewed ontogeny allows the cell to develop in any number of ways, an infinitely easier process than mixing and matching proteins until the correct combination is discovered.

Jacob Newberger (Jake Newberger): management issues

By Jake Newberger (Jacob Newberger)  Jacob Newberger – A mechanical engineer with specialties in robotics and automatic control systems,

The argument that the common notion that workers are generally apathetic about management issues is false or at least outdated is flawed. In this essay, I will discuss the reasoning behind this argument that was presented in the editorial section of a corporate newsletter. One underlying assumption of the argument is that the survey was anonymous.

This assumption is not valid since it is plausible that, for example, the workers were afraid that their answers could affect their status in the corporate. The argument would be made stronger if the survey was taken anonymously.

Another invalid assumption is that the questions were phrased fairly. The flaw here is that the author ignores the possibility that the reviewers of the survey intentionally asked unfair questions. One way of improving the argument is to mention that neutral company prepared the survey.

 

The flaws detailed above suggest that the conclusion presented in the editorial section of a corporate newsletter may not be logically drawn. Therefore it is evident that the line of reasoning is neither sound nor convincing.

Jake Newberger, Jacob Newberger

Jake Newberger : Process Analytical Technology: The Future of Pharmaceutical Manufacturing is Now

By Jake Newberger (Jacob Newberger)

Jacob Newberger – A mechanical engineer with specialties in robotics and automatic control systems,

Process Analytical Technology (PAT) is quickly becoming an integral component in the pharmaceutical and chemical manufacturing industries.  Utilizing a low latency network of powerful chemometric instruments, multivariate data analysis software, process control tools, and a central SQL database, PAT provides pharmaceutical and biopharmaceutical companies an edge over their competitors.

PAT and its benefits are incredible and groundbreaking. Done are they days of a rigid manufacturing line and discarded low-quality batches due to the unforeseen consequences of factory automation “improvements”. Instead, PAT is a flexible system capable of keeping pace with the rapid advances in drug development and manufacture. At the core of any PAT system are a set of Critical Process Parameters (CPPs) that are defined based on the manufacturing equipment itself, and those CPPs will function as the independent variables along the production line. By monitoring physical and chemical properties, the manufacturer can also define a set of variable CPP-dependent variables known as Critical Quality Attributes (CQAs) at various stages of the process, allowing the manufacturer to better understand and control the entire process. These CPPs and CQAs are then used in conjunction with a PAT platform to create both unit-level and high-level process line models capable of predicting the precise quality of the end product. After the predictions are made, adjustments can be made and be fed back into integrated control systems such as Siemens SIMATIC PCS7, fine tuning the manufacturing process to further improve product quality and ensure product consistency.

PAT platforms have been developed by automation industry leaders such as Siemens, and current PAT solutions are supported by a vast number of major analyzer manufacturers such as Mettler Toledo, Thermo Scientific, Kaiser Optical Systems, and the Bruker corporation. The Siemens implementation (SIPAT) is configured to work with these manufacturers by default, however SIPAT will integrate with nearly any analyzer, including those capable of NIR spectroscopy, NMR spectroscopy, or FBRM.

Non-destructive on-line or at-line testing of the product allows the manufacturer to achieve Real Time Release Testing (RTRT) that has been specifically cited by the FDA to increase economic benefit and manufacturing efficiency by lowering laboratory costs and reducing inventory. An FDA white paper from 2004 delves deeper into the benefits of, and can be found at http://www.fda.gov/downloads/Drugs/Guidances/ucm070305.pdf

As modern medicine continues to advance at breakneck speed, the technology used to scale up and manufacture those advances will have to keep pace. PAT is not just evolutionary, but truly revolutionary, analogous to the advent of batch processing twenty years ago, which has now become the industry standard.

A graduate of Penn State’s top-ranked mechanical engineering program, Jake Newberger  (Jacob Newberger)  is an Automation Engineer at Panacea Technologies, Inc., located outside of Philadephia.

Jake Newberger: Robotic Trends for 2013

With advances in technology occurring every month, keeping up with robotic trends for 2013 might be a daunting task. Robotic prosthetics, robot-assisted care giving, and industrial robots continue to be burgeoning fields in 2013, according to Illah Nourbakhsh, who is a professor of robotics at Carnegie Mellon University.

Robotic prosthetics have the ability to do more than simply assist with walking; they can also be used to help the patient build stronger muscles. In terms of robot-assisted care giving, there are already places in Asia where couples leave their children at home while they go out to dinner, and if there is a problem, the robot alerts the parents. However, Nourbakhsh warns that it may still be too risky to leave children in the care of a robot. In addition, industrial robots may help with productivity, but they also cause unemployment because the robots often do the work cheaper and faster than humans could.

As an automation validation engineer for Panacea Technologies, Inc., Jake Newberger troubleshoots distributed control systems. Prior to working with the Pennsylvania-based company, he interned for Prototype Productions based in Virginia where he helped to design surgical simulators. Jacob Newberger graduated in 2011 from Penn State University, where he majored in mechanical engineering.